Abstract
Helicobacter pylori bacterium is one of the most common bacterial infections globally and is the leading cause of indigestion, gastric and duodenal ulcers, and gastric cancer. This bacterium can escape the antibacterial effects of stomach acid by adapting to the inner layers of the stomach. It combines with the natural sugars in the gastric mucosa. The compound is so effective that it makes bacterium resistant. For genes related to the pathogenesis of H. pylori, using the existence of genes such as cagA, hopQI, and hopQII, PCR is performed on some of these genes to amplify fragments of different lengths. One of the less-studied cases is that two or more pathogenic genes are simultaneously associated with H. pylori. This study examined the frequency of diseases and healthy individuals infected with H. pylori and cagA and hopQII genotypes. To diagnose H. pylori infection in healthy and stomach cancer patients, the PCR products are electrophoresed on the agarose gel after glmM gene amplification by PCR. To this aim, stomach tissue biopsies were used for patients, and saliva was used for healthy individuals. For this purpose, 150 gastric biopsy samples from stomach cancer patients and 150 saliva samples from healthy people were collected. Data showed a significant relationship between the coexistence of two genes, cagA and hopQII, and stomach cancer. 34.2% of patients and 10.1% of healthy individuals showed two genotypes, while other healthy people (89.9%) infected with H. pylori did not have this genotype. Therefore, the simultaneous presence of these two bacterial genes in human societies can be an essential biomarker for the diagnosis and prognosis of gastric cancer.
Highlights
Helicobacter pylori bacterium is the most common of this pump is that it can keep the gradient of protons microorganism that infects humans in the world
H. pylori bacterium is a slow-growing microaerobic can be spherical, habitable and pathogenic, but gram-negative bacterium that exists in the stomach cannot be cultured and attached to the and duodenum and is associated with many gastric mucosa
This study aimed to investigate the relationship between cagA and hopQII genes and gastric cancer
Summary
Helicobacter pylori bacterium is the most common of this pump is that it can keep the gradient of protons microorganism that infects humans in the world. More (positive ions) on both sides of the wall at a ratio of than half of the world's population is infected with this one million and transmit any positive ions that enter bacterium. This bacterium is the main cause of the bacteria. There are too diseases such as stomach ulcers and stomach and many proton ions due to the presence of stomach acid If they enter the bacteria, they will destroy it.
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