Abstract
BackgroundSince the first isolation of the Rift Valley Fever virus (RVFV) in 1930s, there have been several epizootics outbreaks in the tropic mainly in Africa including Sudan. Recognition of cases and diagnosis of RVF are critical for management and control of the disease.AimsTo investigate the seroprevalence and risk factors for seropostive to RVFV IgG among febrile patients.MethodsAll febrile patients presented to New Halfa hospital in eastern Sudan during September through November 2007 were investigated to identify the cause of their fever including malaria and RFV.ResultsOut of 290 feverish patients presented to the hospital, malaria was diagnosis in 94 individuals. Fevers of unknown origin were diagnosed in 149 patients. Seropostive to RVFV IgG was detected by enzyme-linked immunosorbent assay in 122 (81.8%) of the sera from these 149 patients with fever of unknown origin. While socio-demographic characteristics (age, Job, education and residency) were not associated with seropostive to RVFV IgG, male (OR = 2.8, 95% CI = 1.0-7.6; P = 0.04) were at three times higher risk for seropostive to RVFV IgG.ConclusionThere was a high seropostive to RVFV IgG in this setting, more research is needed perhaps using other methods like PCR and IGM.
Highlights
The Rift Valley Fever virus (RVFV) of the family Bunyaviridae is a cause of zoonotic viral disease [1]
There was a high seropostive to RVFV immunoglobulin G (IgG) in this setting, more research is needed perhaps using other methods like PCR and IGM
The study was conducted in New Halfa hospital in eastern Sudan during October through December 2007 to investigate the seroprevalence and risk factors for RVFV among febrile patients
Summary
The Rift Valley Fever virus (RVFV) of the family Bunyaviridae is a cause of zoonotic viral disease [1]. Since the first isolation of the virus in1930s, there have been several epizootics outbreaks in tropic mainly in Africa including Sudan, which is the largest country in Africa [2,3]. RVFV Infection in humans can be acquired through mosquito bites, through contact with infected animals and vertical transmission has been reported [4]. RVF can present as uncomplicated acute febrile illness, severe complications, such as hemorrhagic disease, meningoencephalitis, renal failure and blindness have been reported [2,5,6]. Since the first isolation of the Rift Valley Fever virus (RVFV) in 1930s, there have been several epizootics outbreaks in the tropic mainly in Africa including Sudan. Recognition of cases and diagnosis of RVF are critical for management and control of the disease
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