RIFM fragrance ingredient safety assessment, (2-endo,3-exo)-ethyl 3-(1-methylethyl)bicyclo[2.2.1]hept-5-ene-2-carboxylate, CAS registry number 116044-44-1

A.M Api,M Lavelle,A Lapczynski,M Date,J Romine,G Ritacco,J Buschmann,H Moustakas,L Jones,D Selechnik,Y Thakkar,C Deodhar,W Dekant,K Joshi,M Na,F Siddiqi,N Sadekar,D Botelho,D Belsito,G Sullivan,I.g Sipes ,I Lee ,T.m Penning ,G.a Burton ,M.l Dagli ,M.a Cancellieri ,T.w Schultz ,M Kumar ,M Bruze ,A.d Fryer ,D.c Liebler ,Y Tokura

doi:10.1016/j.fct.2021.112624

RIFM fragrance ingredient safety assessment, (2-endo,3-exo)-ethyl 3-(1-methylethyl)bicyclo[2.2.1]hept-5-ene-2-carboxylate, CAS registry number 116044-44-1

A.M Api, M Lavelle + Show 30 more

https://doi.org/10.1016/j.fct.2021.112624

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Journal: Food and Chemical Toxicology

Publication Date: Oct 19, 2021

Affiliation: Research Institute for Fragrance Materials, Universidade de São Paulo, Fraunhofer Institute for Toxicology and Experimental Medicine, Vanderbilt University, University of Würzburg, Oregon Health & Science University, Columbia University Irving Medical Center, University of Michigan–Ann Arbor, Lund University

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Abstract

In addition, the total systemic exposure to (2-endo,3-exo)-ethyl 3-(1-methylethyl)bicyclo[2.2.1]hept-5-ene-2-carboxylate (3.3μg/kg/day) is below the TTC (9μg/kg/day; Kroes, 2007) for the repeated dose toxicity endpoint of a Cramer Class II material at the current level of use.

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