Rice (Oryza sativa L.) bran preserves cardiac function by modulating pro-inflammatory cytokines and redox state in the myocardium from obese rats

Jéssica Leite Garcia,Igor Otávio Minatel,Fabiane Valentini Francisqueti-Ferron,Artur Junio Togneri Ferron,Silméia Garcia Zanati Bazan,Camila Renata Corrêa,Fernando Moreto,Danielle Fernandes Vileigas,Cristina Schmitt Gregolin,Mariane Róvero Costa,Dijon Henrique Salomé De Campos

doi:10.1007/s00394-021-02691-0

Jéssica Leite Garcia, Igor Otávio Minatel + Show 9 more

Open Access

https://doi.org/10.1007/s00394-021-02691-0

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Abstract

PurposeThis study aimed to evaluate the effect of rice bran (RB) supplementation to a high-sugar fat (HSF) diet on cardiac dysfunction in an experimental obesity model.MethodsMale Wistar rats were distributed into three groups: control, high-sugar fat, and high-sugar fat supplemented with 11% RB for 20 weeks.ResultsHSF diet promoted obesity and metabolic complications. Obese rats showed cardiac structural and functional impairment associated with high levels of interleukin-6, tumoral necrosis factor alpha, and malondialdehyde, and decreased activity of superoxide dismutase and catalase in the myocardium. RB supplementation was able to mitigate obesity and its metabolic alterations in HSF diet-fed animals. Moreover, the RB also prevented structural and functional damage, inflammation, and redox imbalance in the heart of these animals.ConclusionThis study suggests that RB supplementation prevents cardiac dysfunction in rats fed on HSF by modulating systemic metabolic complications and inflammation and oxidative stress in the myocardium, representing potential alternative therapy.

Highlights

IntroductionThe contemporary dietary habits, especially the high consumption of processed foods rich in sugar and fat, associated with overnutrition and a sedentary lifestyle, have significantly increased the worldwide prevalence of obesity [1, 2], a complex metabolic disease defined as an abnormal or excessive accumulation of adipose tissue within the body that may impair health [3]
The contemporary dietary habits, especially the high consumption of processed foods rich in sugar and fat, associated with overnutrition and a sedentary lifestyle, have significantly increased the worldwide prevalence of obesity [1, 2], a complex metabolic disease defined as an abnormal or excessive accumulation of adipose tissue within the body that may impair health [3].A consistent body of evidence shows that obesity promotes hemodynamics, neurohormonal and metabolic changes that may contribute to alterations in cardiac structure and ventricular function, progressing to heart failure depending on the duration and severity of obesity [4,5,6]
There is no interference of rice bran (RB) in food, water, and calorie intake since these parameters were similar between high-sugar fat (HSF) and HSF + RB groups (Table 2)

Summary

Introduction

The contemporary dietary habits, especially the high consumption of processed foods rich in sugar and fat, associated with overnutrition and a sedentary lifestyle, have significantly increased the worldwide prevalence of obesity [1, 2], a complex metabolic disease defined as an abnormal or excessive accumulation of adipose tissue within the body that may impair health [3]. A consistent body of evidence shows that obesity promotes hemodynamics, neurohormonal and metabolic changes that may contribute to alterations in cardiac structure and ventricular function, progressing to heart failure depending on the duration and severity of obesity [4,5,6]. The pathophysiology of cardiac dysfunction due to excess adipose tissue is complex. To investigate therapeutic strategies is essential for the prevention and treatment of heart disease owing to obesity [7, 8]

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