Abstract
Psoriatic arthritis is a polymorph inflammatory rheumatism that can lead to severe joint deformities, can have axial manifestations with spine ankyloses and extra-articular features. Peripheral mutilans arthritis are rare, but occurs in patients with early onset disease, are frequently associated with nail psoriasis and often with axial involvement. Clinical inflammation, with polysynovitis, biological inflammation and early erosions are commonly associated with the risk of structural progression. Hip involvement is associated with more severe disease. Axial involvement prevalence is variable according to the definition and the phenotype of the disease is close from axial spondyloarthritis. Peripheral joint erosions, severe psoriasis, early onset disease and HLA-B*0801 are frequently associated with sacroiliitis in psoriatic arthritis. Psoriatic arthritis also impair function, quality of life and work productivity. Beside psoriasis, there is an increased risk of extra-articular features such as uveitis and inflammatory bowel diseases. Psoriatic arthritis can be associated with metabolism syndrome that may increase cardiovascular event risk and thus mortality.
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