Rhodium(III) and Platinum(II) Complexes of Azamacrocycle: Synthesis, Characterization and Antimicrobial Evaluation

Abstract

A dihydroperchlorate salt of octamethyl derivative of 14-membered tetraazamacrocycle, Me8[14]diene·2HClO4 (L·2HClO4), was formed by the condensation of 1,2-diamino propane with acetone in the presence of a quantitative amount of perchloric acid, which on extraction with chloroform at pH above 12 yielded free ligand (L). The interaction of rhodium(III) trichloride trihydrate and platinum(II) chloride with free ligand L produced six-coordinated octahedral orange-red complex, cis-[RhLCl2]Cl and four-coordinated square-planar yellow complex, [PtL]Cl2, respectively. Axial substitution reactions on [RhLCl2]Cl with KX (X = NO3, Br or I) and NaNO2 afforded six-coordinated deep brown products [RhLY2]Y (Y= NO3, Br, I or NO2). The ligand and metal complexes were characterized based on analytical, molar conductivity, spectroscopic and magnetochemical data. The antimicrobial activities of the concerned ligand and its complexes have been explored against some selected bacteria and fungi.