Nickel(II), copper(II) and zinc(II) complexes with an N-pendent dimethyl derivative of an octamethyl macrocyclic ligand: synthesis, characterization and antimicrobial studies

Abstract

Interaction of CH3I with L (3,10-C-meso-Me8[14]diene) in the ratio of 4:1 in ethanolic solution at room temperature yielded N-pendent dimethyl derivative [(L-2H)(–CH3)2] denoted by LZ. Interaction of nickel(II) acetate tetrahydrate with LZ and subsequent addition of NaClO4·6H2O produced square planar orange-yellow product, [NiLZ](ClO4)2. The reaction of copper(II) perchlorate hexahydrate with LZ afforded four coordinated square planar red [CuLZ](ClO4)2. However, on the reaction of zinc(II) nitrate hexahydrate with LZ furnished white six coordinated two distereoisomeric complexes [ZnLZα(NO3)2] and [ZnLZβ(NO3)2]. Axial addition reactions on four coordinated square planar [NiLZ](ClO4)2 with KX (X= SCN, NO3, Cl, Br or I) and NaNO2 resulted in six coordinated octahedral and square pyramidal axial addition products, such as [NiLZ(NCS)2], [NiLZ(NO3)(ClO4)], [NiLZCl(ClO4)], [NiLZBr2], [NiLZI2] and [NiLZ(NO2)](ClO4), respectively. However axial substitution reactions on [ZnLZα(NO3)2] with KY (Y= SCN, Cl or Br) and NaNO2 produced six coordinated octahedral axial substitution products [ZnLZα(NCS)2], [ZnLZαCl2], [ZnLZαBr2] and [ZnLZα(NO2)2]. Similarly, the axial substitution reactions on [ZnLZβ(NO3)2] with KI and NaClO4.6H2O resulted in six coordinated octahedral axial substitution products [ZnLZβI2] and [ZnLZβ(H2O)2](ClO4)2, respectively. The compounds have been characterized by analytical, spectroscopic, magnetochemical and conductivity data. The antimicrobial activities of the new ligand and its complexes have been tested against different micro pathogens. Nickel(II), copper(II) and zinc(II) complexes with an N-pendent dimethyl derivative ligand LZ of an octamethyl tetraazmacrocyclic ligand were prepared. The compounds were characterized by different analytical and spectroscopic methods. Antibacterial and antifungal activities of these compounds against some bacteria and fungi were also investigated.