Abstract
IntroductionCoronary artery disease (CAD) is an ischemic condition that occurs as a result of partial or complete interruption of blood flow by narrowing or complete blockage of the vessels supplying the heart, which are called coronary arteries. Our objective in this study is to investigate the RhoA/Rho-associated kinase (ROCK)-1 signaling pathway and oxidative stress in CAD patients.MethodsA total of 81 individuals aged between 40-70 years - including 45 patients (15 females and 30 males) who were admitted to the Artvin State Hospital Cardiovascular Surgery Clinic and were diagnosed with CAD and 36 healthy volunteers (15 females and 21 males) - participated in this study. Serum samples were tested for total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, malondialdehyde (MDA), superoxide dismutase (SOD), RhoA, and ROCK-1 values.ResultsSerum RhoA, MDA levels, and ROCK-1 activity in the CAD group were found to be statistically significantly higher than in the control group (P<0.001). Concordantly, serum SOD activity was found to be statistically significantly lower in the CAD group than in the control group (P<0.001).ConclusionInhibition of the activity of RhoA/ROCK-1 pathway would be beneficial in treating cardiovascular diseases since this pathway plays an important role in the development of these diseases.
Highlights
Coronary artery disease (CAD) is an ischemic condition that occurs as a result of partial or complete interruption of blood flow by narrowing or complete blockage of the vessels supplying the heart, which are called coronary arteries
In our study aiming to reveal the relationship between MDA and superoxide dismutase (SOD) levels, which are used for evaluating the oxidative stress status of the organism in CAD patients as well as the RhoA/Rho-associated kinase (ROCK)-1 signal pathway, it was observed that RhoA, ROCK-1, and MDA levels of the CAD group increased compared to the control group, and SOD levels decreased
The first reason for this interest is that the RhoA/ROCK signaling pathway plays an important role in various cellular functions involved in the pathogenesis of cardiovascular diseases
Summary
Coronary artery disease (CAD) is an ischemic condition that occurs as a result of partial or complete interruption of blood flow by narrowing or complete blockage of the vessels supplying the heart, which are called coronary arteries[1]. As the leading cause of deaths, CAD is responsible for approximately 48% of deaths in the world population. Atherosclerosis is the primary factor causing CAD, many other reasons such as coronary vasospasm, coronary artery embolism, coronary artery anomalies, vasculitis, rheumatic diseases, and trauma can lead to CAD[3]. Atherosclerosis is a chronic inflammatory disease characterized by the formation of fibrous-fatty plaques called “atheroma” in the intimal layers of the medium and large arteries[4].
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