Abstract
Rhesus M1.3S Cells Suitable for Biological Evaluation of Macaque-Tropic HIV/SIV Clones
Highlights
Binding activity of the corresponding Human immunodeficiency virus type 1 (HIV-1) Gag-CA loop [cyclophilin A (CypA) binding loop (−) in Figure 1A] and the entire simian immunodeficiency virus isolated from macaques (SIVmac) vif gene (Kamada et al, 2006)
MN4–8S contains the h6/7L of SIVmac Gag-CA and three adaptive mutations
Macaque cell lines that are sensitive to various SIV and HIV-1mt clones and maintain the characteristics of natural target cells such as peripheral blood mononuclear cells were not readily available to us
Summary
Binding activity of the corresponding HIV-1 Gag-CA loop [CypA binding loop (−) in Figure 1A] and the entire SIVmac vif gene (Kamada et al, 2006). NL-DT5RS contains a loop sequence between helices 6 and 7 (h6/7L in Figure 1A) of SIVmac Gag-CA relative to NL-DT5R. MN4–8S contains the h6/7L of SIVmac Gag-CA and three adaptive mutations. MN4Rh-3 has an additional mutation in Gag-CA relative to MN4–8S.
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