Abstract
Rhabdomyolysis (RM) has been associated with many viral infectious diseases, and associated with poor outcomes. We aim to evaluate the clinical features and outcomes of RM in patients with coronavirus disease 2019 (COVID-19). This was a single-center, retrospective, cohort study of 1,014 consecutive hospitalized patients with confirmed COVID-19 at the Huoshenshan Hospital in Wuhan, China, between February 17 and April 12, 2020. The overall incidence of RM was 2.2%. Compared with patients without RM, those with RM tended to have a higher risk of deterioration. Patients with RM also constituted a greater percentage of patients admitted to the intensive care unit (90.9% vs. 5.3%, P < 0.001) and a greater percentage of patients undergoing mechanical ventilation (86.4% vs. 2.7% P < 0.001). Moreover, patients with RM had laboratory test abnormalities, including the presence of markers of inflammation, activation of coagulation, and kidney injury. Patients with RM also had a higher risk of in-hospital death (P < 0.001). Cox's proportional hazard regression model analysis confirmed that RM indicators, including peak creatine kinase levels > 1,000 IU/L (HR = 6.46, 95% CI: 3.02-13.86) and peak serum myoglobin concentrations > 1,000 ng/mL (HR = 9.85, 95% CI: 5.04-19.28), were independent risk factors for in-hospital death. Additionally, patients with COVID-19 that developed RM tended to have delayed viral clearance. RM might be an important contributing factor to adverse outcomes in COVID-19 patients. The early detection and effective intervention of RM may help reduce mortality among COVID-19 patients.
Highlights
Acute respiratory distress syndrome (ARDS) was the leading cause of adverse outcome of coronavirus disease 2019 (COVID-19) patients, the contribution of other organs dysfunction had remained largely unknown [1, 2]
We aimed to determine the prevalence of RM among patients with COVID-19 and to investigate the association between RM-related indicators and in-hospital death in patients infected with COVID-19
The diagnosis of RM might be important for predicting the adverse outcomes of patients with COVID-19
Summary
Acute respiratory distress syndrome (ARDS) was the leading cause of adverse outcome of coronavirus disease 2019 (COVID-19) patients, the contribution of other organs dysfunction had remained largely unknown [1, 2]. The above findings indicated that RM maybe an important complication of COVID-19, the present studies still lacking enough cases to comprehensively understand the clinic features and outcomes of RM in patients with COVID-19. We conducted this large cohort study of COVID-19 patients in a major designated hospital for COVID-19 infection in Wuhan, China. We aimed to determine the prevalence of RM among patients with COVID-19 and to investigate the association between RM-related indicators and in-hospital death in patients infected with COVID-19
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