Abstract
<h3>Development and Proof of a Hypothesis</h3> The accompanying case report by Levine and Stetson<sup>1</sup>is a fine example of the importance of careful clinical observation. Some may scoff at the publication of case reports, but to the astute scientist, a carefully documented study of an unusual patient represents an experiment of nature that may be the opportunity to explain a long-recorded but unexplained clinical mystery. Some credit must also go to the editorial staff ofThe Journalfor having published this and a related landmark, "Isoimmunization in Pregnancy: Its Possible Bearing on the Etiology of Erythroblastosis Foetalis," by Levine et al.<sup>2</sup> A new era in the clarification of the nature of erythroblastosis was opened by the classic observation of Diamond and colleagues<sup>3</sup>that icterus gravis, hydrops fetalis, and anemia of the newborn with erythroblastosis represented different grades of clinical severity of the same unknown underlying process. They
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