Abstract
ERYTHROBLASTOSIS fetalis has long been recognized as a hemolytic disease of unknown origin with varying degrees of anemia and hepatic damage. The historical aspect of the problem has been thoroughly covered by Javert,<sup>1</sup>Potter<sup>2</sup>and others. The forms manifested by the illness were individually described by many writers, and a relationship between fetal hydrops, icterus gravis and congenital hemolytic anemia of the newborn was assumed in 1932.<sup>3</sup>Other unclassified varieties of the syndrome are known to exist.<sup>4</sup> Therapy, even before the recent elucidation of the pathogenesis, was directed at correction of the anemia by repeated transfusions. This treatment proved effective in some instances, but in the majority of cases there were severe reactions, with increased hemolysis, fever and death. These reactions are now known to have been caused by the use of Rh-positive blood from random donors, and from the fathers, whose erythrocytes always carried the
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
