Abstract
Energy homeostasis is maintained by a complex interplay between central and peripheral signals that gather information on the nutritional status. The integration of these signals by the central nervous system (CNS) results in a response adapted to a change in nutrient availability. The arcuate nucleus (ARC) of the hypothalamus contains neurons that release the Neuropeptide Y and Agouti-related protein (NPY/AgRP) and that are considered as first-order neurons in the integration of peripheral signals of satiety and hunger like leptin, insulin or ghrelin. Other central structures including the hindbrain or the mesolimbic dopaminergic system, as well as multiple central signals, act in combination with the “hypothalamic” regulation of food intake and provide potential targets for the development of therapeutic strategy in the prevention of abnormal feeding behavior like anorexia, or at the opposite hyperphagia.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
