Abstract
Readout of epigenetic modification has provided us with plentiful information to thoroughly understand the regulation of genes during myogenic differentiation. While skeletal myogenesis is coordinated by sequential expression of myogenic regulatory factors including MyoD and myogenin, chromatin modifications have emerged as vital mechanisms of myogenic regulation. We have recently found that bexarotene, a retinoid X receptor (RXR)‐selective agonist, promotes the specification and differentiation of muscle lineage; however, the genome wide impact of rexinoid action on myogenic expression has not yet been investigated. Through genome wide association studies, we here determined rexinoid‐responsive residue‐specific histone acetylation at a distinct chromatin state associated with MyoD and myogenin. We also define a new mechanism of rexinoid action which is mediated by the receptor and largely reconciled through a direct regulation of MyoD expression. Thus, we provide novel molecular insights into the interplay between retinoid X receptor signaling and chromatin states associated with myogenic programs in early differentiationSupport or Funding InformationNSERCThe Cancer Research societyIRSCThis abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Published Version
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