Abstract
The aim of the present research was to formulate and evaluate immediate release tablet of apixaban. In this research study, we are formulating apixaban by wet granulation method. Previously research has been conducted based on dry granulation and direct compression methods.
 The proposed wet granulation method has several advantages in terms of feasibility and cost effectiveness. The present formulation comprises of comparative evaluation between disintegrants such as sodium starch glycolate (SSG), and croscarmellose sodium (CCS), among which CCS was found to have optimum results. Superdisintegrants, are compounds that, as their name implies, are superior to disintegrants and that facilitate or enhance the disintegration time even at low levels, usually 1-10% by weight relative to the total weight of the dosage unit. These are used to boost the potency of the solid dosage form.
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