Abstract
Objective: The main objective of this research work was to formulate and evaluate fast dissolving tablet of verapamil hydrochloride for the treatment of hypertension.Methods: In this study, fast dissolving tablet were prepared by wet granulation method by using croscarmellose sodium and sodium starch glycolate as superdisintegrants in the concentration of 2%, 4%, and 6%. Polyvinyl pyrollidone K30 is used as a binder. The designed tablets were subjected to various assessment parameters like friability test, hardness test, disintegration test, wetting time, in vitro drug release and drug content.Results: All the prepared formulations were subjected to various assessment parameters, and the findings obtain within the prescribed limit. The calibration curve of pure drug using various solvents like distilled water, phosphate buffer pH 6.8 was plotted. F1-F9 containing croscarmellose sodium and sodium starch glycolate in various concentration demonstrate the minimum disintegration time. Among all these formulations F8 shows disintegration time upto 19±0.06 seconds due to the high concentration of superdisintegrants. In vitro drug release was tested in phosphate buffer pH 6.8 at a time interval of 0, 1, 3,6,9,12,15 min. The F8 shows drug release 98.5±0.567%. Accelerated stability study of optimized formulation (F8) up to 2 mo showed there was no change in disintegration time and percentage drug release.Conclusion: The results obtained in the research work clearly showed a promising potential of fast dissolving tablets containing a specific ratio of crosscarmellose sodium and sodium starch glycolate as superdisintegrants for the effective treatment of hypertension.
Highlights
Oral drug delivery remains the preferred route for administration of various drugs
Determination of λ max of verapamil hydrochloride λ max of verapamil hydrochloride was determined in water
The IR spectra of verapamil hydrochloride, polymers, and physical mixture are shown in figures
Summary
Oral drug delivery remains the preferred route for administration of various drugs. Solid dosage forms are popular because of ease of administration, accurate dosage, self-medication, pain evasion and most importantly the patient compliance. To solve the abovementioned problem, pharmaceutical technologists have put in their best efforts to develop a fast dissolving drug delivery, i.e. mouth dissolving tablet that disintegrates and dissolves rapidly in the saliva, within a few seconds without the need of drinking water or chewing. Such formulations provide an opportunity for product line extension in the many elderly persons will have difficulties in taking conventional oral dosage forms (viz., solutions, suspensions, tablets, and capsules) because of hand tremors and dysphagia. The technologies utilized for fabrication of fast dissolving tablet include lyophilization, molding, direct compression, cotton candy process, spray drying, sublimation, mass extrusion, nanonization, and quick dissolve film formation
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