Revisiting the question of toxidermia classification

Abstract

In connection with the upcoming transition to the International Classification of Diseases and Health-related Problems of the eleventh revision (ICD-11), the authors of the article propose to replace the term toxidermy with a new, widely used in the world term drug-induced skin reactions. The article presents a list of various variants of drug-induced rashes, which are included in the draft ICD-11. For standardization of definitions and diagnostic criteria, a unified working classification of this group of diseases is based on a mixed principle clinical manifestations (primary morphological elements of skin rash), etiological and pathogenetic aspects are taken into account. The applied unified classification of drug-induced skin reactions is proposed for discussion. Examples of the formulation of clinical diagnoses are given. Severe drug-induced skin reactions are described, which are potentially life-threatening for the patient, can lead to disability and require mandatory hospitalization.