Abstract
The TMEM16F is a Ca2+ activated phospholipid scramblase. Its activation causes the rapid collapse of the lipid asymmetry of the plasma membrane and results in the exposure of the negatively charged phosphatidylserine (PS) lipid on the cell surface. This is an essential step in important physiological processes, such as blood coagulation, viral entry and cell fusion. Despite the physiological importance of this process, the mechanisms of Ca2+-dependent gating and of lipid scrambling of TMEM16F remain poorly understood.
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