Abstract
Extrachromosomal circular DNAs (eccDNAs) can be originated from the sequences of chromosomes, and have high heterogeneity in origin. In different surroundings, the production of eccDNAs involves various generation model and repair mechanisms. Technologies as high throughput sequencing (HTS) greatly help to identify more eccDNAs. Recently, eccDNAs were found in human circulating system. EccDNAs can affect cell life activities, promote tumor cell adaptive evolution and increase the genome plasticity and instability. EccDNAs show great potential in diagnosis, prognosis prediction and treatment of tumors and in liquid biopsy as well. The purpose of this review is to elucidate the research progress on the origin, function, study strategy and potential utility of human eccDNAs. Key words: Extrachromosomal circular DNA; Episome; Double minutes; Small polydispersed circular DNA; microDNA; Liquid biopsy
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
