Abstract
Ocular drug delivery remains demanding because of the complex nature and structure of the eye. predictable systems, such as eye drops and ointments, are inefficient, whereas systemic administration requires high doses resulting in major toxicity. SLNs are specially useful in ocular drug delivery as they can improve the corneal absorption of drugs and improve the ocular bioavailability of both hydrophilic and lipophilic drugs. SLNs have another advantage of allowing autoclave sterilization, a essential step towards formulation of ocular preparations. In-vitro and in-vivo methods to study the drug release profile of SLNs have been explained. Special attention has been given to the nature of lipids and surfactants frequently used for SLN production. A summary of preceding studies involving the use of SLNs in ocular drug delivery is provided, along with a significant evaluation of SLNs as a potential ocular delivery system. Aspects of solid lipid nanoparticles route of administration and their biodistribution are also integrated. If appropriately investigated, solid lipid nanoparticles may open new vistas in therapy of complex diseases.
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