Review on Optimization base Emulgel Formulation

Abstract

The aim of the present research work is to decrease the systemic side effects and to create a more pronounced effect of emulgel of tretinoin with lower doses of the drug. Emulgel emerged as one of the most interesting topical drug delivery system as it has dual release control system. Also the stability of emulsion is increased when it is incorporated into gel. The emulgel was developed using polymers like carbopol 940 (1: 1) of gel and emulsion. Drug-excipients interaction was characterized by FTIR studies. The topical emulgel was prepared by preparing emulsion and gel separately and incorporation emulsion into the gel. The emulgel was evaluated for their physical appearance, pH evaluation, Spreadability, rheological study, drug content, in vitro permeation study and stability study. After all evaluation it can be concluded that tretinoin emulgel could increase the drug permeability across the membrane and fast release of the drug could be achieved successfully. Objective and aim-The aim of present study was to develop an emulgel formulation of Tretinoin gel using Carbopol 940 or HPMC as a gelling agent. The influence of the type of gelling agent and the concentration of both the oil phase and emulsifying agent on the release of the drug and its microbial activity were investigate using 23 factorial design in addition, rheological properties were also evaluated. Conclusion-The present work is to develop tretinoin emulgel adaptable topical drug delivery systems which provide protection against oxidation, fast absorption, and prolonged release and enables reduction in dose and evaluate the emulgel using an ideal topical drug candidate of Tretinoin by suitable method with its release. Tretinoin is widely used in topical acne treatment at 0.025% and 0.05% concentrations. Tretinoin is very effective in 0.05% strength but it cause skin erythema on the applied area.