Review on in-situ nasal gel drug delivery system

Abstract

The review was carried out to discuss in detail about the in-situ gel nasal drug delivery system as these system have better systemic bioavailability through nasal route as compared to oral route of administration. In-situ gel is a novel dosage form for nasal delivery of various drugs. It is infusing into the nasal cavity as low viscous solution and after sometime it forms gel when it contact with the nasal mucosa. The main advantage of using nasal delivery is avoidance of first pass metabolism, high permeability of some drugs in nasal epithelium, quick drug absorption across this membrane, rapid onset of action, improved patient compliance and comfort, sustained and prolonged action in comparison to other drug delivery systems. The formation of gel depends on factors like temperature modulation, pH change, and presence of ions, ultra violet irradiation, polymorphism, dissolution rate, solubility, viscosity and osmolarity. The review was focused on anatomy and physiology of nose, advantages, disadvantages, mechanism of drug delivery to the nose, types of dosage form for nasal delivery, barriers in nasal drug delivery, factors influencing nasal absorption, mucoadhesive polymer used in nasal drug delivery system and evaluation of in-situ gel nasal drug delivery system.