Review on domestic published papers regarding the acute disseminated encephalomyelitis and its relations with rabies vaccination

Abstract

To explore whether the case of acute disseminated encephalomyelitis (ADEM) who had been inoculated with rabies vaccination reported in domestic literatures were related to the vaccination. Data on 1368 cases of ADEM (from 99 papers) were collected by computer from the Chinese Journal Full-text Database in CNKI and Wanfang database with the key words of acute disseminated encephalomyelitis/rabies vaccination/abnormal reaction in preventive vaccination during 1995 and 2011. All the cases were divided into the two queues according to the situation of rabies vaccination. Cohort study was used to analyze the relations between ADEM and vaccination. The incidence of ADEM, standardized by age that having received immunization with rabies vaccine, was 9.41/1 million person year, higher than 0.29/1 million person year (u = 428.35, P < 0.01) among those who had not. Among people who had been inoculated, the adjusted RR value of cause ADEM was 31.05 (95%CI: 26.33 - 36.62). RR values increased along with the times of rabies vaccine injection. Correlation was seen between inoculated rabies vaccine and ADEM.