Abstract
Background:Lymphatic filariasis is a tropical disease and currently more than 1.4 billion people in 73 countries are at risk but still it is neglected in higher researches. Lymphatic filariasis is wide spread throughout the tropical and subtropical areas of Asia, Africa, the Western Pacific and some parts of the Americas. Though it is a big issue for developing countries but still no proper prophylactic or therapeutic measures are taken out as to protect against filarial infection or to modulate disease.Objective:Non availability of proper prevention or cure as well are the major issues for which new scientific computational research approaches towards the management and betterment of this disease is required. Identification of novel compounds or drug targets through advance computational approaches can give new and better alternatives against this social problem or can open a new gate way towards advance approaches of drug designing.Results:Current review signifies the contribution of scientist working in different areas are globally thinking about the resolution of this problem and among different approaches these computational based researches will no doubt are a milestone against the fight with filaria. Genomic, proteomic, system biology based concepts, computational drug designing, virtual screening, homology modellingetc. are the different advances which altogether will win these problem.Conclusion:Compilation of thisin silicocontributions are well establishing their importance in finding out new targets and compounds that could lead a milestone against this social stigma which create humiliation not only for patients or relatives but also burden of society too.
Highlights
Lymphatic filariasis or elephantiasis is a tropical disease and currently more than 1.4 billion people in 73 countries are at risk but still it is neglected in higher researches [1], it is widespread throughout the tropical and subtropical areas of Asia, Africa, the Western Pacific and some parts of the Americas [2, 3]
Proteomic, system biology based concepts, computational drug designing, virtual screening, homology modelling etc. are the different advances which altogether will win these problem in terms of proper medication or finding out preventions against the devil of filaria which causes social stigma and mental and physical trauma to the victim of this disease. Compilation of this in silico contributions are well establishing their importance in finding out new targets and compounds that could lead a milestone against this social stigma, which creates humiliation for patients or relatives and a burden for society
Current study was planned to understand the mechanism involved to explore out the possible therapeutic interventions related to Filariasis disease, commonly known as elephantiasis, is a painful and profoundly disfiguring disease, caused by the parasitic filarial nematodes Wuchereria bancrofti (W. bancrofti), Brugia malayi (B. malayi), or Brugia timori (B. timori)
Summary
Lymphatic filariasis is a tropical disease and currently more than 1.4 billion people in 73 countries are at risk but still it is neglected in higher researches. Lymphatic filariasis is wide spread throughout the tropical and subtropical areas of Asia, Africa, the Western Pacific and some parts of the Americas. Though it is a big issue for developing countries but still no proper prophylactic or therapeutic measures are taken out as to protect against filarial infection or to modulate disease
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