Review of the twelfth West Coast retrovirus meeting

Sheila M Barry,Thomas J Hope,Philippe Gallay,Marta Melar

doi:10.1186/1742-4690-2-72

Sheila M Barry, Thomas J Hope + Show 2 more

Open Access

https://doi.org/10.1186/1742-4690-2-72

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Abstract

Every year the Cancer Research Institute from University of California at Irvine organizes the West Coast Retrovirus Meeting where participants have a chance to discuss the latest progress in understanding the pathology of retroviruses. The 12th meeting was held at the Hyatt Regency Suites in Palm Springs, California from October 6th to October 9th 2005, with the major focus on human immunodeficiency virus (HIV) pathogenesis. Philippe Gallay from The Scripps Research Institute and Thomas J. Hope from Northwestern University organized the meeting, which covered all the steps involved in the lifecycle of retroviruses with an emphasis on virus:host interactions. The trend in research appeared to be on the restriction of viral infection, both by the endogenous, cellular restriction factors, as well as by the potential antimicrobial compounds of known or unknown mechanisms. Additionally, new stories on the inevitable feedback from the host immune system were presented as well. HIV still represents a challenge that an army of motivated people has been working on for over 20 years. And yet, the field has not reached the plateau in knowledge nor enthusiasm, which was proven again in October 2005 in Palm Springs.

Highlights

Pankaj Kumar from Lorraine Albritton's lab at the University of Tennessee continued this theme by examining cellular factors involved in Moloney Murine Leukemia Virus (MLV) entry
In work previously published by his lab, John Day of the University of California San Diego and others determined the membrane proximal tyrosine based sorting signal of gp41, Y712xxL, was important in viral entry and infectivity and was involved in virion incorporation of the envelope glycoprotein (Env) only in some cell lines [2]
When these signals were evaluated with CCR5 tropic HIV1, neither the LL855/86 nor the Y712xxxL sorting signal had any effect on viral infectivity

Summary

Introduction

Pankaj Kumar from Lorraine Albritton's lab at the University of Tennessee continued this theme by examining cellular factors involved in Moloney MLV entry. In work previously published by his lab, John Day of the University of California San Diego and others determined the membrane proximal tyrosine based sorting signal of gp41, Y712xxL, was important in viral entry and infectivity and was involved in virion incorporation of the envelope glycoprotein (Env) only in some cell lines [2].

Results

Conclusion