Abstract
Shaping of the host cell by viral accessory proteins.
Highlights
Optimal viral replication relies on the ability of viruses to use cellular resources and to overcome the intracellular defense mechanisms
The importance of accessory proteins can be evidenced as inefficient viral spread, delay in replication curves or low viral loads upon disruption of their corresponding open reading frames (ORF) in non-permissive cells and in vivo
This review collection aims at discussing recent advances in our understanding of manipulation of host cells by the human immunodeficiency virus (HIV) type 1 (HIV-1) and type 2 (HIV-2), with a particular focus on viral accessory proteins
Summary
Optimal viral replication relies on the ability of viruses to use cellular resources and to overcome the intracellular defense mechanisms. Major functions of these accessory proteins may be grossly classified as: (i) counteraction of cellular restriction factors (ii) escape from innate immune sensing, (iii) disturbance of cellular pathways, and (iv) enhancement of viral infectivity. This review collection aims at discussing recent advances in our understanding of manipulation of host cells by the HIV type 1 (HIV-1) and type 2 (HIV-2), with a particular focus on viral accessory proteins.
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