Abstract
Traditional Chinese Medicine (TCM) has a long history and rich experience in treating Heart Failure (HF), with good clinical effect and little side effects. Saponins, as one of the active substances in TCM, have a variety of pharmacological activities, wide sources and low toxicity, and their functions can not be ignored. Further research on the role of saponins in the treatment of HF found that saponins have the advantages of multi-level, multi-target and multi-channel comprehensive regulation effects, which has important research and development value in the treatment of HF. Through the analysis and summary of the related literatures on the mechanism of treating HF with saponins, it is found that saponins can improve heart function mainly by inhibiting inflammatory reaction, regulating energy metabolism disorder, resisting myocardial ischemia, inhibiting myocardial apoptosis and other ways. The purpose of this paper is to further explore the mechanism of saponin in treating different HF, and to provide further ideas and references for the research and drug development and application of TCM in preventing and treating HF.
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