Abstract
Background:The incidence of food allergy is a growing health concern in the United States. Research suggests that there is a link between the gut microbiota and the development of allergy. As a result, researchers propose that gut microbial populations could affect the development and management of immunological disease.Objectives:The purpose of this review is to present current evidence of the advantages and disadvantages of probiotic and/or prebiotic addition to extensively hydrolyzed protein (EHF) and amino acid-based infant formulas (AAF) for the management of food allergy.Method:Only randomized controlled trials were included for review. The randomized controlled trials were limited to human subjects less than 12 years of age with a confirmed case of food allergy who were consuming EHF or AAF supplemented with probiotics and/or prebiotics.Results:Eleven studies were included for review. Probiotic and synbiotic addition was associated with an improvement in SCORAD index in EHF and AAF, and EHF significantly moderated immunologic and/or inflammatory responses. Probiotic addition to EHF benefited patients exhibiting hematochezia, and synbiotic addition resulted in softer stool, higher stool frequency, and decreased incidence of infection in some studies.Conclusion:Although few studies report statistically significant effects upon feeding prebiotics or probiotics with EHF and AAF on food allergy, this review sheds light on evidence that such inclusion may have positive impacts on SCORAD index, stool quality, immunologic and inflammatory factors, and incidence of infection.
Highlights
The incidence of food allergy has increased worldwide and is a growing health concern in the United States, where an estimated 6% of children under 3 years of age and approximately 4% of adults are affected [1]
While the results of this review suggest that the advantages associated with probiotic and/or prebiotic addition to hypoallergenic formulas improved skin conditions and SCORAD index, decreased incidence of hematochezia and infection, improved inflammatory and immunological factors, improved fecal characteristics, and supported normal growth, very few studies reported a statistically significant effect of feeding prebiotics or probiotics
This review shows that a possible driving factor for the effectiveness of probiotic and/or prebiotic supplementation in hypoallergenic formula on SCORAD index is the level of total or specific Immunoglobulin E (IgE) in subjects in the treatment group
Summary
The incidence of food allergy has increased worldwide and is a growing health concern in the United States, where an estimated 6% of children under 3 years of age and approximately 4% of adults are affected [1]. The risk of developing food allergies varies based on age, race, gender, and genetic factors. Examination (NHANES) survey found that non-Hispanic blacks, males, and children exhibit increased risk for the development of food allergies [2]. Non-IgE-mediated reactions include villous atrophy, eosinophilic proctocolitis, enterocolitis, and esophagitis and are associated with the consumption of cow’s milk, soy, and other dietary proteins. The incidence of food allergy is a growing health concern in the United States. Researchers propose that gut microbial populations could affect the development and management of immunological disease
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
