Abstract

Background: The impact of oral nutritional supplementations (ONS) is not well-elucidated in children with stunting. Objective: The aim is to evaluate the effect of ONS on growth in Vietnamese children with stunting. Methods: This 6-month, prospective, single-arm trial evaluated 121 children aged 24–48 months with stunting (height-for-age z-score [HAZ] < -2) and low weight-for-height z-score (WHZ < -1) in Vietnam. Children consumed ONS twice daily. The outcomes included the change in HAZ, WHZ, and weight-for-age z-score (WAZ) from baseline to 3- and 6 months; change in height and weight from baseline to 3- and 6 months; and the prevalence of stunting, wasting (WHZ < -2 SD), and underweight (WAZ < -2 SD) at 6 months. We also examined factors associated with a change in HAZ over the intervention period. Results: The mean age was 34.7 months and 49% were male. Height and weight increased from baseline to 3- and 6-months (p<0.0001). There was a significant increase in median HAZ (0.25 units), WHZ (0.72 units), and WAZ (0.65 units) from baseline to 6 months (p<0.0001). Notably, approximately 40% of children recovered from stunting at 6 months (p<0.0001). The prevalence of wasting and underweight status were also significantly lower at 6 months (p=0.0310 and p<0.0001, respectively) relative to the baseline. Lower HAZ and younger age at baseline were significantly associated with higher linear growth at 6 months. Conclusion: ONS helped improve linear and ponderal growth and reduce the prevalence of stunting, wasting, and underweight status in stunted children at risk of wasting.

Highlights

  • Stunting affected 151 million children under the age of 5 in 2017, with more than half of these children living in Aishwarya Sridharan from in vivo Communications (Asia) [1]

  • We examined the efficacy of oral nutritional supplementations (ONS) on linear and ponderal growth in preschool children with stunting and low weight-for-height z-score (WHZ < -1) in Vietnam

  • Our study suggests that nutritional intervention in stunted children older than 2 years is effective in promoting catch-up linear growth, which could potentially mitigate the adverse consequences of stunting

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Summary

Introduction

Stunting affected 151 million children under the age of 5 in 2017, with more than half of these children living in Asia [1]. Several challenges may limit the effectiveness of a food-based approach in developing countries [23]. In Vietnam, family foods typically comprise of rice, legumes, oilseeds, vegetables, sugar, salt, and monosodium glutamate, which have high antinutrient content and low density in terms of macro- and micronutrients [7, 18, 24]. There is poor consumption of fruits, fish, and animal-based foods in Vietnam [7]. Another challenge of using DC to overcome stunting is that it requires dietary diversity [20] and may be difficult to implement considering the aforementioned issues related to food insecurity and diversity in Vietnam. Dietary recommendations for moderately stunted children are non-specific and this may limit their effectiveness for catch-up growth [21]. The impact of oral nutritional supplementations (ONS) is not well-elucidated in children with stunting

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