Review of Captopril Drug Formulation, Mechanism of action, Dosage, Use and Adverse drug reactions

Abstract

Hypertensive crisis is a condition characterized by rapid and inappropriate symptomatic elevation of blood pressure that is commonly seen in Emergency Department. Oral or Sublingual Captopril is commonly used in the emergency department. The unpleasant tast of the sublingual drugs causes uncomfortable condition to the patient. Studies showing on difference between oral and sublingual Captopril has been ignored sofar. Herein we compared the oral and sublingual Captopril efficiency in the hypertensive urgencies. However clinical use requires the daily dose of 37.5- 75 mg to be taken at three times. The reason being the drug is highly water soluble, unstable in alkaline intestinal PH and decrease in bioavailability in presence of food. Various attempts have been made to regulate the release and increase the bioavailability of the drug. The treatment course was 2 weeks. After that, we compared angina, blood pressure, ECG and adverse drug reactions of the two group.