Abstract
This article is an extension of a discussion started in the first part of a series of review articles, entitled “Can Toxic Substances Initiate Psychotic Behavior? Part I. Antimalarial Drugs” in (Open Journal of Preventive Medicine). In the present manuscript, the environmental, health, reproduction (fecundity), social, and juridical problems, together with the medical and ethical aspects of the use of organophosphate substances, will be discussed. This article is based mainly on the results of experiments conducted during the period of 2004–2014. The results described in the article entitled “High-Performance Liquid Chromatography (HPLC) Equipped with a Neurophysiological Detector (NPD) as a Tool for Studying Olfactory System Intoxication by the Organophosphate (OP) Pesticide Diazinon and the Influence of OP Pesticides on Reproduction” (International Journal of Analytical Mass Spectrometry and Chromatography) will be discussed in connection to human disability (invalidation) caused by OPs. The results showed that even a short-time, sub-lethal exposure to the anti-acetylcholinesterase enzyme OPs yields altered neural signaling. These perverse nervous signals can change the basic information that is transmitted to the brain. This information regarding the external environment surrounding situation is vital for living organisms. The exposure of organisms to OPs can have a lifelong impact on the nervous system and be a source of adverse psychotic reactions, even after a single exposure. This article stresses the need for a moratorium on (or, even better, the prohibition of) the use of OPs in agricultural and veterinary practices as pesticides, and the recognition of the use of OPs against the civilian population as chemicals to control protests and demonstrations (as protesto- and demonstrationocides) as a criminal act.
Highlights
After exposure of the olfactory organs to diazinon, the Sex Pheromones provoked nervous activity in the olfactory bulb (OB), which can be decoded by the brain as signals from the exposure of the olfactory epithelium (OE) to Alarm Substance(s)
This can partly explain the psychopathological action of OPs on the central nervous system (CNS), and, as a result, the inadequate reaction observed in fish
These behavioral changes may be the source of the insufficient or demising reproducibility observed in fish stocks
Summary
This article is an extension of a discussion started in the first part of a series of review articles, entitled “Can Toxic Substances Initiate Psychotic Behavior? Part I [1]. The deep involvement of pesticides and insecticides in the normal physiological process of all living creatures, including plants and mammals, is obvious The selectivity of these substances toward target organisms (compared with their toxic effects on other non-target living systems) is very low. Pesticides often have other unpredicted toxic side effects [8] This project was started by the invitation of the author of this review article to help the team of scientists regarding the isolation and molecular elucidation of an elusive pheromone described by K. von Frisch in 1942 [9] and named Schreckstoff by him. Instrumentation with a much more powerful detection sensitivity than that available at the time was necessary This equipment was constructed based on HPLC [2] [3] and the available software described in these articles and the olfactory system of the living fish Carassius carassius L.
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