Abstract
Trichloroethylene (TCE) may induce oxidative stress which generates free radicals and alters antioxidants or oxygen-free radical scavenging enzymes. The aim of this study was to investigate the protective role of oral administration of kombucha tea in rats with TCE as an environmental pollutant. Methods: Twenty male albino rats were divided into four groups: the control group treated with vehicle, Kombucha (KT)-treated group, TCE-treated group and KT/TCE-treated group. Liver and kidney lipid peroxidation, glutathione content, nitric oxide (NO) and total blood free radical concentrations were evaluated. Serum urea, creatinine level, gamma-glutamyl transferase (GGTP) and lactate dehydrogenase (LDH) activities were also measured. Results: TCE administration increased the malondialhyde (MDA) and NO contents in liver and kidney, urea and creatinine concentrations in serum, total free radical level in blood and GGTP and LDH activities in serum, whereas it decreased the glutathione (GSH) level in liver and kidney homogenate. KT administration significantly improved lipid peroxidation and oxidative stress induced by TCE. Conclusion: The present study indicates that Kombucha may repair damage caused by environmental pollutants such as TCE and may be beneficial to people who deal with these chemicals.
Highlights
Kombucha is a sour beverage prepared from the fermentation of black tea and sugar with a symbiotic culture of acetic acid bacteria and yeasts such as Bacterium xylinum, Bacterium xylinoides, Bacterium gluconicum, Saccharomyces ludwigii, Saccharomyces apiculatus varieties, Schizosaccaromycespombe, Acetobacter ketogenum, Torula varieties, Pichia fermantans and other yeasts reported to have potential health effects, Morales, G.B. and Sanchez H.H. (2003)
KT administration significantly improved lipid peroxidation and oxidative stress induced by TCE
The present study indicates that Kombucha may repair damage caused by environmental pollutants such as TCE and may be beneficial to people who deal with these chemicals
Summary
Kombucha is a sour beverage prepared from the fermentation of black tea and sugar with a symbiotic culture of acetic acid bacteria and yeasts such as Bacterium xylinum, Bacterium xylinoides, Bacterium gluconicum, Saccharomyces ludwigii, Saccharomyces apiculatus varieties, Schizosaccaromycespombe, Acetobacter ketogenum, Torula varieties, Pichia fermantans and other yeasts reported to have potential health effects, Morales, G.B. and Sanchez H.H. (2003). Kombucha is a sour beverage prepared from the fermentation of black tea and sugar with a symbiotic culture of acetic acid bacteria and yeasts such as Bacterium xylinum, Bacterium xylinoides, Bacterium gluconicum, Saccharomyces ludwigii, Saccharomyces apiculatus varieties, Schizosaccaromycespombe, Acetobacter ketogenum, Torula varieties, Pichia fermantans and other yeasts reported to have potential health effects, Morales, G.B. and Sanchez H.H. Fermentation and oxidation processes of Kombucha microorganisms produce a wide range of organic acids, vitamins and enzymes. Glucuronic acid is one of the organic acids produced during fermentation process in Kombucha and may improve oxidative metabolism, Blanc, P. Trichloroethylene (TCE) is a major environmental contaminant and an occupational concern due to its widespread industrial use, Davidson, I. TCE is nephrotoxic as well as hepatotoxic and causes both hepatic and renal tumors in rats, Maltoni, C. et al (1988). The toxicity of TCE depend on its reactive metabolites derived from the reaction of either glutathione conjugating nor P450 with TCE, the reaction of
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