Abstract
CLINICAL concentrations of the inhalational anaesthetic halothane (2-bromo-2-chloro-l,l,l-trifluoroethane stabilized with 0.01 per cent thymol, supplied as ‘Fluothane’; ICI) strikingly reduce the motility of certain non-mammalian cells including the slime mould Physarum polycephalum and the ciliate Tetrahymena pyriformis. Less is known of the effect of anaesthetics on the motility of mammalian cells, but Bruce1 has reported that, in mice, halothane anaesthesia suppresses the mobilization of neutrophils in response to intraperitoneal injection of Salmonella typhimurium and decreases phagocytosis.
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