Abstract

As the blueprint of vital activities of most living things on earth, DNA has important status and must be protected perfectly. And in current DNA databases, each sequence is stored with several notes that help to describe that sequence. However, these notes have no contribution to the protection of sequences. In this paper, the authors propose a reversible data hiding method for DNA sequences, which could be used either to embed sequence-related annotations, or to detect and restore tampers. When embedding sequence annotations, the methods works in low embedding rate mode. Only several bits of annotations are embedded. When used for tamper detection and tamper restoration, all possible embedding positions are utilized to assure the maximum restoration capacity.

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