Abstract
Reverse mode Na+/Ca2+ exchange-induced cell dehydration as a primary mechanism for cell pathology
Highlights
Na+/K+ pump is a fundamental metabolic mechanism in cell membrane which controls cell functional activity
We have previously shown that Na+/K+ pump-dependent regulation of cell volume is a powerful metabolic mechanism through which both the auto-regulation of Na+/K+-pump [10] and the regulation of membrane chemosensitivity [11] and excitability [8] are realized by changing surface-dependent number of functionally active proteins in membrane
The increase of [Ca2+]i, which is accompanied by Na+/K+ pump inactivation, is considered as a result of intracellular Na+ concentration ([Na+]i) increase which stimulates Ca2+ uptake through Na+/Ca2+ exchange in reverse mode (R Na+/Ca2+ exchange) [12]
Summary
Na+/K+ pump is a fundamental metabolic mechanism in cell membrane which controls cell functional activity. It is known that the dysfunction of Na+/K+ pump, which is accompanied by the increase of intracellular Ca2+ concentration ([Ca2+]i), is a common consequence of any cell pathology (including aging).
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