Abstract
At least two genes found in the genome of Asterias rubens after immunizations to the antigen Horse-Radish Peroxydase (HRP), could play the role of oncologic markers: The first one (Igkappa chain V-V region T 1 S 107 B precursor) reveals myeloma; The second (B cell CLL/Lymphoma 9-like) as the first one has a kinship to the IgKappa gene subfamily.
Highlights
Leclerc and Vincent (2013) the sea star genome with Swissprot data, revealed, for the first time, a sea star Igkappa gene, in response to Horse-Radish Peroxydase (HRP) immunizations.On the other hand, oncologic markers, of the IgKappa subfamily, were found
It appears that the gene: Igkappa chain V-V region T 1 is present, in a significant manner in the genome of immunized sea star to the antigen HRP
It is interesting to find in the sea star genome such oncologic markers which are linked for the first one to mouse myeloma (Altenburger et al, 1980), for the second one to lymphoma (Toya et al, 2007)
Summary
Leclerc and Vincent (2013) the sea star genome with Swissprot data, revealed, for the first time, a sea star Igkappa gene, in response to HRP immunizations. Oncologic markers, of the IgKappa subfamily, were found. At our knowledge, it is the first time, that such phenomenon was described
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