Abstract
An efficient synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives from the three-component condensation reaction of phthalhydrazide, dimedone, and aromatic aldehydes under solvent-free conditions in good to excellent yields and short reaction times using reusable silica supported poly phosphoric acid (PPA–SiO2) as heterogeneous acid catalyst has been investigated.
Highlights
An efficient synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives from the three-component condensation reaction of phthalhydrazide, dimedone, and aromatic aldehydes under solvent-free conditions in good to excellent yields and short reaction times using reusable silica supported poly phosphoric acid (PPA–SiO2) as heterogeneous acid catalyst has been investigated
In the past few decades, the synthesis of new heterocyclic compounds has been a subject of great interest due to their wide applicability
Among a large variety of heterocyclic compounds, heterocycles containing the phthalazine moiety are of interest because they show some pharmacological and biological activities.[4]
Summary
An efficient synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives from the three-component condensation reaction of phthalhydrazide, dimedone, and aromatic aldehydes under solvent-free conditions in good to excellent yields and short reaction times using reusable silica supported poly phosphoric acid (PPA–SiO2) as heterogeneous acid catalyst has been investigated. First, the effect of temperature on the rate of the reaction was studied for the preparation of 2,2-dimethyl-13-phenyl-2,3-dihydro-1H-indazolo[2,1-b]phthalazine4,6,11(13H)-trione from the three-component condensation reaction of phthalhydrazide, dimedone, and benzaldehyde under solvent-free conditions (Table 1).
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