Abstract
Retroviral insertional mutagenesis (RIM) is a well known adverse effect in gene therapy trials which can lead to leukemia or preleukemic conditions. However, it can also serve as a powerful tool to study cancer and stem cell biology by studying genes adjacent to insertion sites. This study is to demonstrate the capacity of RIM to study proto-oncogenes in stem cell regulation and their potential collaborating partners in leukemogenesis. By recording retroviral insertion sites from hematopoietic dominant clones in murine bone marrow transplantation (BMT) model, our group has developed the Insertional Dominance Database (IDDb).
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