Retrospective dosimetric analysis of brain lesions planned in Pinnacle 9.8 via a HDMLC linac

Abstract

The University of Toledo Medical Center's Eleanor N. Dana Cancer Center located in northwest Ohio currently utilizes the Edge Radiosurgery System (Varian Medical Systems Inc., Palo Alto, CA) to deliver stereotactic radiosurgery for the treatment of brain lesions. The purpose of this study is to determine the quality of conformal arc radiotherapy in treating patients with brain lesions at The University of Toledo Medical Center and to provide more data for conformity and gradient indices (due to a lack of current data) to hopefully improve national standards by allowing centers to compare among each other. Treatment plans were assessed using the Pinnacle3 v9.8 Radiation Therapy Planning System (Philips Healthcare, Amsterdam, Netherlands). For patients (n = 41) presenting with small brain lesions (n = 82) and treated with conformal arc radiotherapy via the Edge Radiosurgery System, the RTOG conformity index, Paddick conformity index, conformity gradient index, gradient index, and dose gradient index were determined for each plan. This study additionally provides data to suggest the more accurate method of volume derivation provided by the Pinnacle3 v9.8 software. Using this method, average values for each of the following indices were calculated: RTOG conformity index = 1.36 ± 0.29; Paddick conformity index = 0.72 ± 0.12; conformity gradient index = 214.67 ± 12.35; gradient index = 3.64 ± 1.09; dose gradient index = −0.11 ± 0.16. Thus, The University of Toledo Medical Center provides favorable conformity of dose to intracranial target lesions.