Retrospective Comparative Study between Results of Neo Adjuvant Chemotherapy and Upfront Surgery in Breast Cancer in Aswan Oncology Center

Abstract

Abstract Background Breast cancer is a global health problem, with more than 1 million cases of breast cancer diagnosed worldwide each year. Introduction of neoadjuvant chemotherapy (NACT) has dramatically changed the management of breast cancer. Aim and Objectives To compare the clinicopathological features, surgical procedures, and outcome parameters of primary and post-neoadjuvant chemotherapy breast conseravtive surgery, with the aim of comparing the outcomes in terms of ipsilateral breast tumor recurrence rates and over all free survival in the two groups. Subjects and Methods This was a Comparative study, was conducted in Aswan oncology center on (40) women diagnosed with breast cancer, divided into two groups: (Group A): 20 up front surgery patients then adjuvant chemoherapy, (Group B): 20 Neo adjuvant chemotherapy then surgery patients during 6 months. Result There was statistically significant difference between the two studied groups as regard Metastatic work up and local recurrence. Conclusion The neoadjuvant chemotherapy has a nearby significant impact on pathological complete response (PCR) in patients with breast cancer with no significant increased toxicity and has significant lower rates of metastasis compared to upfront surgery.Neoadjuvant chemotherapy followed by surgery is a safe and effective rather than conventional method (primary surgery followed by Adjuvant chemotherapy) in treatment of Breast cancer.