Abstract
Abstract Background: Splendore-Hoeppli phenomenon is a localized host immunologic reaction to antigens of a variety of infectious and non-infectious agents. It results in nodules of material composed of antigen-antibody complexes, tissue debris, and fibrin. It is believed to be a localized immunological response to an antigen-antibody precipitate related to microbes or inert materials. It is associated worldwide mostly with fungal infections and in the United States with certain bacterial infections including Actinomyces israelii, Nocardia spp., and chronic infections of Staphylococcus spp., Streptococci, Proteus, Pseudomonas, and Escherichia coli. It is observed in various locations including skin, subcutaneous tissue, and conjunctiva causing chronic wounds. Interestingly, it can also be induced by inert materials such as silk sutures. However, the majority of literature and case reports identify association of this reaction with chronic infections. Case Presentation: A patient developed a chronically dr...
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