Abstract
MicroRNAs (miRNAs) have been proved involved in many tumorigenic behaviors including tumor growth. But, the clinical significance and functions of miRNA-203 in gastric cancer (GC) remain elusive. Decreased expression of miRNA-203 was correlated with tumor size, poor prognosis and recurrence in GC patients. Overexpression of miR-203 or knockdown of its target progesterone immunomodulatory binding factor 1 (PIBF1) inhibited GC growth in vitro and in vivo, while miR-203 knockdown promoted GC proliferation. In addition, PIBF1 overexpression attenuated the inhibitory effects of miR-203 on GC growth and enhanced that effect on p-Akt expression. MiR-203 as a tumor biomarker suppresses GC growth through targeting the PIBF1/Akt signaling, suggesting that it may have the important therapeutic potential for the treatment of GC.
Highlights
Retraction The authors are retracting this article [1] because it was brought to the Editor’s attention that two images appear to be similar to others within the same article and one image appears to be similar to an image in Zhang et al [2], as detailed below: The two tubulin/HGC-27 bands in Fig. 4b [1] and the first two EGFR bands in the HGC-27 panel of Fig. 5b [1]
Peng-Fei Zhang and Yun-Min Lu have not responded to our correspondence about this retraction
Received: 27 March 2017 Accepted: 4 April 2017
Summary
Retraction The authors are retracting this article [1] because it was brought to the Editor’s attention that two images appear to be similar to others within the same article and one image appears to be similar to an image in Zhang et al [2], as detailed below: The two tubulin/HGC-27 bands in Fig. 4b [1] and the first two EGFR bands in the HGC-27 panel of Fig. 5b [1]. The two tubulin/HGC-27 bands in Fig. 4b [1] and the first two EGFR bands in the HGC-27 panel of Fig. 5b [1].
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