RETRACTION: Antisense inhibition of Bcr-Abl/c-Abl synthesis promotes telomerase activity and upregulates tankyrase in human leukemia cells.

Abstract

R. Bakalova, H. Ohba, Z. Zhelev, T. Kubo, M. Fujii, M. Ishikawa, Y. Shinohara, and Y. Baba, 'Antisense inhibition of Bcr-Abl/c-Abl synthesis promotes telomerase activity and upregulates tankyrase in human leukemia cells,' FEBS Letters 564, no. 1-2 (2004): 73-84, https://doi.org/10.1016/S0014-5793(04)00318-7. The above article, published online on 9 April 2004 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; the journal Editor-in-Chief, Michael Brunner; FEBS Press; the National Institute of Advanced Industrial Science and Technology (AIST); and John Wiley and Sons Ltd. Following publication, concerns were raised by a third-party regarding several figures in the article. The subsequent institutional investigation conducted by the AIST revealed: Inappropriate duplication of image panels within the article, between the β-actin loading controls for 4 and 6 days in the Western blot of Fig. 2A K-562; between the subpanels of the electrophoresis blots in Fig. 4A K-562 and Jurkat cells; and between the subpanels of the electrophoresis blots in Fig. 6B. Band insertion in the Western blot of Fig. 6A p210 Bcr-Ab lane. Inappropriate duplication of images between this article (Fig. 2A K562 β-actin and Fig. 4B K562 6 days treatment bands) and an earlier publication from 2003 by an overlapping group of authors representing different experimental conditions. Inappropriate duplication and modification of an image between this article (Figure 3A2) and an earlier publication from 2004 by an overlapping group of authors representing different experimental conditions. Therefore, the conclusions of the paper are substantially compromised and the institute has recommended the paper to be retracted. The editors of the journal agree with the retraction based on the institutional investigation.