RETRACTED: Two Zn(II) coordination complexes: Gas separation property and treatment activity on chronic pulmonary interstitial disease and mechanism exploration

Abstract

Abstract Two anion-directed Zn(II) coordination complexes of {[Zn2 (acc)1.5 (phen)2](NO3) (MeOH)5}n (1, H2acc = 4-carboxycinnamic acid, phen = 4-carboxycinnamic acid) and [Zn2 (acc) (phen)4](ClO4)2(H2O)8 (2) were synthesized and characterized via powder X-ray diffraction (PXRD) and single crystal X-ray diffraction and elemental analysis. Furthermore, the microporosities and the coordinately unsaturated Zn(II) sites enabled the activated complex 1 to reveal preemptive gas adsorption of CO2 and C2H2 instead of CH4. The high selectivity for C2H2 to CH4 was predicted on the basis of the calculations of IAST, which revealed the potential application of 1 in CH4/C2H2 selective isolation in the industry. Furthermore, the protective effect of complexes 1–2 on chronic pulmonary interstitial disease was evaluated. The chronic pulmonary interstitial disease animal model was established and complexes 1–2 were given for indicated treatment. The real time RT-PCR was carried out to determine the kgf7 gene relative expression level in the lung epithelial cells. To explore the mechanism, the ELISA detection kit was used for the measurement of the inflammatory cytokines IL-18 and TNF-α content.