RETRACTED: Two transition metal coordination polymers: Fluorescent sensing property and capability of treating neuropathic pain via regulating the ephrinBs-EphBs signaling pathway

Abstract

Abstract By using a tripodal ether-connector tricarboxylic ligand 1,3,5-tris(carboxymethoxy)benzene (H3TCMB) as the organic linker, two new transition metal coordination polymers (CPs) were synthesized via reaction of Zn(NO3)2•6H2O or Co(NO3)2•6H2O with H3TCMB ligand under the solvothermal reaction conditions, and their chemical formulae are [Co3(TCMB)2(H2O)4]n•4nH2O (1) and [Zn3(TCMB)(μ3 OH)3]n•0.5nH2O (2). The single crystal X-ray diffraction study shows that complex 1 is a 2D layered network which is further extended into a 3D supramolecular network via H-bond interactions, and complex 2 shows a 2D layered structure based on a [Zn3(μ3 OH)3]n cluster-based unit. As expected, complex 2 displays excellent luminescence in the solid state and solution, and it could serve as an ultrasensitive fluorescent sensor for detection of 2,4,6-Trinitriphenol (PA). The therapeutic activity of these two compounds on neuropathic pain was evaluated. First, the expression levels of ephrinB receptor were detected via the real-time RT-PCR method, the results showed that ephrinB receptor expression levels in the sciatic nerve was significantly reduced by compound 1, but compound 2 did not show such effect. Then, the EphB ligand content was determined through the ELISA test, the results indicated that compound 1 was found more effective than compound 2 in reducing the content of EphB in the sciatic nerve.