Abstract
ObjectivesWe have assessed the risk factors for the occurrence of hospital-acquired (HA) and community-acquired (CA) viral acute respiratory tract infections (ARTIs) in children. Children (1–60 months) who were having ARTI on admission (CA) and develops ARTI following 48 h after admission or 3 days of discharge (HA) were included. Indirect immunofluorescence assay (IFA) was performed and multivariable analyses were done to determine the risk factors for the development of viral CA and HA-ARTI.ResultsTotal of 818 with ARTIs, 226 (27.6%) RSV cases were detected. Out of 226, 86 (38.0%) HA-RSV cases were detected. CA-viral-ARTI was significantly high (p < 0.05). Compared to CA-RSV-ARTI immunodeficiency, seizures, trisomy-21 and congenital heart disease (CHD) were having 2.3, 3.2, 1.8- and 2.2-times risk for acquiring HA-RSV respectively. The number of deaths was significantly high following HA-RSV. The associated burden was significant following HA-RSV and it was 429.77 disability-adjusted life years. Children who are having immunodeficiency, CHD, seizure episodes and trisomy 21 would lead to the acquisition of nosocomial RSV infections in great. Adherence to meticulous infection control practices will be helpful to minimize the HA-viral ARTIs in great.
Highlights
The study was performed at the children’s ward of the Professorial Unit, Teaching Hospital Anuradhapura, Full list of author information is available at the end of the article (THA), Sri Lanka from March 2015 to August 2016
respiratory syncytial virus (RSV) was significantly associated with recurrence acute respiratory tract infections (ARTIs) admissions (p = 0.04)
T Table 1 Incidence/100,000-person years for hospital acquired and community acquired RSV, PIV-1, PIV-2 and PIV-3, AV, E Inf-A, Inf-B and Human metapneumovirus (hMPV) among of children with ARTI compared to overall incidence
Summary
Study design This was a cross-sectional study. The study was performed at the children’s ward of the Professorial Unit, Teaching Hospital Anuradhapura, Full list of author information is available at the end of the article (THA), Sri Lanka from March 2015 to August 2016. (child aged 1–60 months) who fibrosis), development of seizure in at ward among has admitted for different diseases and develops ARTI known epilepticus and genetic disorders; Down’s synfollowing 48 h after admission or 3 days of discharge drome-trisomy 21; neuromuscular disorders and pre-. For the recruitment of the latter group, pieces of advice were given and a telephone interview was conducted on days-2 and 3 following discharge by the investigator to assess the development of ARTI within 3 days. ARTI cases include all children were having severe acute respiratory tract infection (SARI) on admission and development of ARTI following discharge [5]. Indirect immunofluorescence assay (IFA) [specificity was 99% and sensitivity was 38%] was performed by DAKO IMAGENTM (United Kingdom), respiratory screening reagents for eight respiratory viruses and viral typing was done existing respiratory tract morbidity, passive smoking D viruses using monoclonal antibodies DAKO IMAGENTM (United Kingdom) [11]
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