Abstract
In this study, a porous MOF [Zn2(L)(H2O)2](DMA)2 (1) based on a custom-designed diisophthalate ligand bearing an aromatic-rich backbone were prepared by reaction of zinc(II) nitrate and terphenyl-3,3″,5,5″-tetracarboxylic acid (H4L) in a mixed solvent of DMA, 1,4-dioxane and water with the help of HBF4. Various characterization methods such as single X-ray diffraction, powder X-ray diffraction, thermogravimetric analysis and the gas sorption measurements were used to character the as-prepared 1 and the resulting solvent-free 1a. Compared with 1, the resulting activated 1a exhibits highly efficient catalytic activity for cyanosilylation of carbonyl compounds with a low catalyst loading of 1 mol% under solvent-free conditions, which was due to the open Zn2+ sites as catalytically activated sites played a significant role in the heterogeneous catalytic process. CCK-8 assay was performed to detected the viability of SW60 colon cancer cells, and the cells migration and invasion ability was detected by transwell assay. Besides, the Annexin V/PI Apoptosis Kit was used to measure the level of cell apoptosis after compound treatment.
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