Abstract
We examined the effects of 9-cis retinoic acid (RA) on the expression levels of retinoid X receptor α (RXRα) and its phosphorylated form (p-RXRα) in HL-60 and HL-60R cells. 9-cis RA reduced both RXRα and p-RXRα in HL-60 cells, but did neither in HL-60R cells. However, when the HL-60R cells were treated with the combination of 9-cis RA plus PD98059, MEK inhibitor, the p-RXRα and RXRα proteins all markedly decreased. Moreover, the combination of those agents induced apoptosis in HL-60R cells. Phosphorylation of RXRα might be associated with RA-resistance in HL-60R cells.
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