Retinal Ven Tıkanıklığı ve Bir Oksidatif Stres Belirteç Olan Tiyol-Disülfit Dengesi Arasında İlişki Var Mıdır?

Abstract

Objective: In this study, it is aimed to investigate the dynamic thiol-disulfide homeostasis which is an indicator of oxidative stress in retinal vein occlusion patients. Material and Methods: Thirty nine retinal vein occlusion patients and 38 age-gender matched control subjects were included in the study. Exclusion criteria for retinal vein occlusion group were: ocular history and symptoms exceeding 3 weeks, any other history of ocular disease except the retinal vein occlusion, any previous ocular surgeries or lasers, any previous treatment or intra-vitreal injection for the retinal vein occlusion, any other systemic disease except the arterial hypertension. The control group included patients without any ocular or systemic diseases. Native thiol, total thiol, disulfide levels were studied in the serum samples of all participants and native/total thiol and disulfide/total thiol ratios were calculated as percentage. Results: Total thiol, native thiol, disulfide, native/total thiol and disulfide/total thiol ratio were not significantly different between the retinal vein occlusion and the control groups. In the control group, age was inversely correlated with the total thiol level, but not with the other serum parameters. In the retinal vein occlusion group, there was no correlation among the age and the serum parameters but the body mass index (BMI) was inversely correlated with the total thiol level. Conclusion: There was not any significant difference between the retinal vein occlusion patients and the control subjects for the thiol-disulfide homeostasis.