Abstract
Retinal pigment epithelial (RPE) cells in culture, as well as freshly dissected embryonic RPE, exhibit a β-adrenergic receptor. Agonist potency is: l-isoproterenol > (−)epinephrine ≥ (−)norepinephrine ⪢ dopamine. Propranolol blocks this effect. Hydroxybenzylpindolol (HYP), a β-antagonist, also blocks the increase in cAMP elicited by l-isoproterenol. Binding of [ 125I]-hydroxybenzylpindolol, shows a half saturation concentration of 1·1 × 10 −9, m and 2·7 × 10 5 HYP binding sites per cell. The presence of such distinct β-adrenergic responsiveness indicates a potentially important role for this receptor in RPE cell physiology.
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